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BHMT rs651852 Allele choice

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  • BHMT rs651852 Allele choice

    Although the C allele is more common than T (plus strand), it appears that the rarer allele is actually the more beneficial one, and hence why NutraHacker reports the rarer allele as 'expected.'

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667971/

    The T allele is associated with higher B12 and folate levels.

    Deletion of BHMT leads to a 35% decrease in folate levels in mice (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196139/), indicating that this snp is not simply using those vitamins at a lower rate. In any case, the C allele has lower levels of the vitamins and so supplementation could be beneficial. This is probably only a concern if the individual is homozygous, not heterozygous.
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